Like the rest of the Seychelles Islands Praslin is close to the equator making annual temperatures a steady 80°F (27°C). Praslin experiences its dry season from May to October and the rainy season from December until March. Praslin, and most of the Seychelles, experiences high humidity and heavy rainfall during the December to March monsoon period; however, the southeast winds from May to October can also sometimes bring afternoon showers, which are a welcome relief after a hot day in the sun.

Health regulations in the Seychelles require that travellers from areas infected by yellow fever have a vaccination certificate. Immunisation against hepatitis A, hepatitis B and typhoid are recommended. Visitors are advised to bring their own medication to avert the risk of travellers' diarrhoea, as well as sun block and insect repellent, as local supplies can be erratic and costly. During the rainy season in particular, visitors should take precautions against mosquito bites due to the risk of dengue fever and the chikungunya virus (although these diseases are rare in Seychelles). Tap water meets WHO standards, but most visitors prefer to drink bottled water, which is widely available. Medical facilities on the more remote islands are limited or non-existent, but visitors will find a government hospital and several private clinics in Victoria. Medical insurance with full evacuation cover is necessary.

No foreigners require a visa to enter Seychelles. A visitor's permit, valid for a maximum of one month, is issued on arrival and may be extended on application for up to three months. All visitors do, however, require a passport valid for the duration of their visit, a return or onward ticket, sufficient funds to cover their stay (a minimum of USD 150 per day), and proof of accommodation. Extensions are possible if applied for at least a week before expiry of visitor's permit. It is highly recommended that passports have at least six months validity remaining after your intended date of departure from your travel destination. Immigration officials often apply different rules to those stated by travel agents and official sources.

Safety is not generally an issue in the Seychelles; violent crime is unlikely and most visits are trouble-free. There have been some incidents of theft and assault, but these are targeted mainly at residents. Visitors should be vigilant, particularly after dark in Victoria and in isolated areas. Avoid taking valuables to the beach, where they could be pilfered by petty thieves. Women should avoid walking alone on isolated beaches.